Inadequate reporting of COVID-19 clinical studies: a renewed rationale for the Sex and Gender Equity in Research (SAGER) guidelines

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The COVID-19 pandemic has brought to the fore the implications of sex and gender differences to human health and well-being.1Evidence to date indicates that men are at higher risk of severe disease and death than women, while women seem more likely to suffer from long-term COVID-19, and experience negative social and economic impacts.2 3 Biological sex as well as gender roles and behaviours can affect exposure to the virus and influence the prevalence of pre-existing conditions or harmful habits.4Incorporating sex and gender considerations into clinical research on COVID-19 from the outset would help to identify differential patterns of risk, underlying reasons for disparate outcomes and to develop interventions to effectively respond to the various needs of women and men.5 Given the growing recognition of the relevance of sex and gender in the COVID-19 pandemic, the rationale for this analysis was to examine whether these dimensions are taken into account in clinical research on COVID-19.

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